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KMID : 0616120120430010027
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 1 p.27 ~ p.31
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Inhibitory Effect of Cirsium japonicum Root or Flower Extract on Hepatic Stellate Cells Activation
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Kim Sang-Jun
Kim Seon-Young
Kim Ji-Ae
Park In-Sun
Chung Chang-Ho
Shim Jae-Suk
Jang Seon-Il
Jeong Seung-Il
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Abstract
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This study was designed to elucidate the effects of Cirsium japonicum (CJ) extracts on hepatic stellate cells (HSCs, LX-2 cells) proliferation, which is induced by platelet-derived growth factor (PDGF) or transforming growth factor-β (TGF-β). The content of total phenol, flavonoid, and silymarin derivatives was more higher in CJ-flower than in CJ-root. Consistent with these results, the LX-2 cells growth inhibition was more effective in CJ-flower extract than in CJ-root extract, the complete growth inhibition concentration was 1 μg/mL and 50 μg/mL , respectively. These results suggest that extracts from CJ-flower can be potentially used as therapeutic substances for the regulatioin of HSCs activation.
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KEYWORD
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Cirsium japonicum, Hepatic stellate cells, LX-2 cells, Liver fibrosis, Silymarin
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